Preparation, characterization, and evaluation of azoxystrobin nanosuspension produced by wet media milling

Preparation and Characterization of Nanosuspension of Aprepitant by H96 Process.

PURPOSE Nanosuspension in drug delivery is known to improve solubility, dissolution and eventually bioavailability of the drugs. The purpose of the study was to compare particle size of nanosuspensions prepared by the first generation approach and H96 approach and to evaluate the effectiveness of H96 approach. METHODS The nanosuspension of aprepitant was prepared by HPH and H96 approach. The ...

preparation, optimization and in vitro characterization of nanosuspension of cyclosporine

Characterization of a riboflavin non-aqueous nanosuspension prepared by bead milling for cutaneous application.

The purpose of this study was to characterize the non-aqueous nanosuspension of a hydrophilic drug prepared by bead milling for cutaneous application. Riboflavin was used as the model hydrophilic drug. The non-aqueous nanosuspensions were prepared by grinding riboflavin with zirconia beads using eight non-aqueous bases. The mean particle size of riboflavin in the suspensions ranged from 206 to ...

A stable hydrocortisone nanosuspension for improved dissolution: Preparation, characterization and in vitro evaluation.

Drug nanosuspensions have gained tremendous attraction as a platform in drug delivery. In the present work, a nanosuspension was prepared by a wet milling approach in order to increase saturation solubility and dissolution of the water insoluble drug, hydrocortisone. Size of the generated particeles was 290 nm ± 9 nm having a zeta potential of -1.9 mV ± 0.6 mV. Nanosized particles were found to...

Plant-Mediated Synthesis of Silver Nanoparticles and Their Stabilization by Wet Stirred Media Milling

Within this study, a stable nanosuspension of silver nanoparticles (Ag NPs) was prepared using a two-step synthesis and stabilization approach. The Ag NPs were synthesized from a silver nitrate solution using the Origanum vulgare L. plant extract as the reducing agent. The formation of nanoparticles was finished upon 15 min, and subsequently, stabilization by polyvinylpyrrolidone (PVP) using we...